Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

Yunje Cho, Svetlana S. Gorina, Philip D. Jeffrey et al. · Science · 1994 · 2.5K citations

Life Sciences, Molecular Biology, Oncology +16

Tumor spectrum analysis in p53-mutant mice

Tyler Jacks, Lee Ann Remington, Bart O. Williams et al. · Current Biology · 1994 · 2.1K citations

Medicine, Cancer Biology, Oncology +12

Impact of mutant p53 functional properties on<i>TP53</i>mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

Audrey Petitjean, Ewy A. Mathé, Shunsuke Kato et al. · Human Mutation · 2007 · 1.6K citations · Full text

Medicine, Genetics, Oncology +16

Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome

Kenneth P. Olive, David A. Tuveson, Zachary C. Ruhe et al. · Cell · 2004 · 1.3K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome

Gene A. Lang, Tomoo Iwakuma, Young‐Ah Suh et al. · Cell · 2004 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Genetics +15