Stepwise Insertion and Inversion of a Type II Signal Anchor Sequence in the Ribosome-Sec61 Translocon Complex

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Steffan N. Ho, Henry D. Hunt, Robert M. Horton et al. · Gene · 1989 · 7.5K citations

Life Sciences, Biotechnology, Molecular Biology +10

X-ray structure of a protein-conducting channel

Bert van den Berg, William Clemons, Ian Collinson et al. · Nature · 2003 · 1.3K citations

Natural Sciences, Biochemistry, Biophysics +14

Molecular code for transmembrane-helix recognition by the Sec61 translocon

Tara Hessa, Nadja M. Meindl‐Beinker, Andreas Bernsel et al. · Nature · 2007 · 738 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.

Ute C. Krieg, Peter Walter, Arthur E. Johnson · Proceedings of the National Academy of Sciences · 1986 · 335 citations

Life Sciences, Biochemistry, Molecular Biology +11

Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore

Kathleen S. Crowley, Shuren Liao, Veronica Worrell et al. · Cell · 1994 · 334 citations

Life Sciences, Biochemistry, Cell Biology +14