Concepedia

Sec61 Complex

The Sec61 Complex is a heterotrimeric membrane protein-conducting channel in the endoplasmic reticulum membrane that mediates the co-translational translocation of nascent polypeptides into the secretory pathway by selectively facilitating their passage in conjunction with the signal recognition particle receptor and ribosome.

268

Publications

22.2K

Citations

1.1K

Authors

307

Institutions

Publications per year

2017–2026

76

Variants

Sec61Sec61 ChannelSec61 Translocon

Parents

Publications

268

Molecular code for transmembrane-helix recognition by the Sec61 translocon

Tara Hessa, Nadja M. Meindl‐Beinker, Andreas Bernsel et al. · Nature · 2007 · 738 citations · Full text

, , +15

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

Calvin H. Jan, Christopher C. Williams, Jonathan S. Weissman · Science · 2014 · 466 citations

, , +13

A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

Dirk Görlich, Siegfried Prehn, Enno Hartmann et al. · Cell · 1992 · 461 citations

, , +12

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

Marinus Pilon · The EMBO Journal · 1997 · 403 citations · Full text

, , +12

Sec61p and BiP directly facilitate polypeptide translocation into the ER

Sylvia L. Sanders, Joseph P. Vogel, Mark D. Rose et al. · Cell · 1992 · 378 citations

, , +5

1–5 of 268

Authors

1.1K

  1. RZ
    Richard Zimmermann

    Saarland University, Germany

    33 publications · 2.1K citations

    23

    h-index

  2. SH
    Stephen High

    University of Manchester, United Kingdom

    26 publications · 1.6K citations

    22

    h-index

  3. TA
    Tom A. Rapoport

    Harvard University, United States

    19 publications · 2.8K citations

    19

    h-index

  4. SL
    Sven Lang

    Saarland University, Germany

    15 publications · 838 citations

    13

    h-index

  5. KR
    Karin Römisch

    University of Cambridge, United Kingdom

    14 publications · 502 citations

    13

    h-index

1–5 of 1.1K

Institutions

307

  1. University of Manchester

    Manchester, United Kingdom

    26 h-index

    121 publications

    7.9K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    26 h-index

    61 publications

    9K citations

  3. Saarland University

    Saarbrücken, Germany

    23 h-index

    212 publications

    13.2K citations

  4. Harvard University

    Cambridge, United States

    15 h-index

    44 publications

    6.2K citations

  5. Max Delbrück Center

    Berlin, Germany

    13 h-index

    45 publications

    8.1K citations

  6. University of California, Berkeley

    Berkeley, United States

    11 h-index

    31 publications

    5.8K citations

  7. University of Massachusetts Chan Medical School

    Worcester, United States

    11 h-index

    33 publications

    3.4K citations

  8. Heidelberg University

    Heidelberg, Germany

    11 h-index

    46 publications

    5.6K citations

1–8 of 307

Venues

  1. Journal of Biological Chemistry

    JBC · 34 publications · 2.3K citations

    27

    h-index

  2. The Journal of Cell Biology

    JCB · 22 publications · 2.5K citations

    22

    h-index

  3. Journal of Cell Science

    20 publications · 1.5K citations

    19

    h-index

  4. Molecular Biology of the Cell

    MBC · 17 publications · 1.7K citations

    17

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 792 citations

    10

    h-index

1–5