Concepedia

Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab

Jacqueline Benson, Clifford Sachs, George Treacy, Honghui Zhou, Charles Pendley, Carrie Brodmerkel, Gopi Shankar, Mary Ann Mascelli

Nature Biotechnology · 2011 · 142 citations · 62 references

DOI

Concepts

References

62

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Timothy R. Mosmann, Holly Cherwinski, M W Bond et al. · The Journal of Immunology · 1986 · 7.5K citations

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Claire L. Langrish, Yi Chen, Wendy M. Blumenschein et al. · The Journal of Experimental Medicine · 2005 · 4K citations · Full text

, , +17

A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Richard H. Duerr, Kent D. Taylor, Steven R. Brant et al. · Science · 2006 · 3K citations · Full text

, , +17

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Jonathan Sherlock, Yi Chen, Craig A. Murphy et al. · Nature · 2003 · 2.9K citations

, , +14

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

Birgit Oppmann, Robin Lesley, Bianca Blom et al. · Immunity · 2000 · 2.8K citations · Full text

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