Monoclonal antibody-induced cytokine-release syndrome

Peter J. Bugelski, Ram Achuthanandam, Renold J. Capocasale, +2

Expert Review of Clinical Immunology

InflammationCytokineAutoimmune DiseaseFew MabsImmunology +12

Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab

Jacqueline Benson, Clifford Sachs, George Treacy, +5

Nature Biotechnology

InflammationCytokineAutoimmune DiseaseImmunologyTherapeutic Targeting +8

Predictive power of preclinical studies in animals for the immunogenicity of recombinant therapeutic proteins in humans.

Peter J. Bugelski, George Treacy

PubMed

ImmunodeficienciesHumoral ResponseImmunologyImmunodominancePathology +14

Prevention of Experimental Autoimmune Encephalomyelitis in Common Marmosets Using an Anti-IL-12p40 Monoclonal Antibody

Herbert Brok, Marjan van Meurs, Erwin L. A. Blezer, +6

The Journal of Immunology

ImmunodeficienciesAnti-il-12p40 Monoclonal AntibodyImmunologyImmune RegulationCell Death +20

Effects of an Anti‐TNF‐α Monoclonal Antibody, Administered Throughout Pregnancy and Lactation, on the Development of the Macaque Immune System

Pauline L. Martin, Satoru Oneda, George Treacy

American Journal of Reproductive Immunology

Anti-TNF-α antibody allows healing of joint damage in polyarthritic transgenic mice

David J. Shealy, Paul H. Wooley, Eva Emmell, +7

Arthritis Research & Therapy

Development in the cynomolgus macaque following administration of ustekinumab, a human anti‐il‐12/23p40 monoclonal antibody, during pregnancy and lactation

Pauline L. Martin, Clifford Sachs, Noritaka Imai, +4

Birth Defects Research Part B Developmental and Reproductive Toxicology

Suppression of Ongoing Disease in a Nonhuman Primate Model of Multiple Sclerosis by a Human-Anti-Human IL-12p40 Antibody

Bert A. ‘t Hart, Herbert Brok, Ed Remarque, +7

The Journal of Immunology

White MatterImmunologyImmune SystemImmunotherapyHuman-anti-human Il-12p40 Antibody +18

Absence of Adverse Effects in Cynomolgus Macaques Treated with CNTO 95, a Fully Human Anti-αv Integrin Monoclonal Antibody, Despite Widespread Tissue Binding

Pauline L. Martin, Qun Jiao, Joel B. Cornacoff, +11

Clinical Cancer Research

Effects of Administration of a Monoclonal Antibody against Mouse Tumor Necrosis Factor Alpha during Pregnancy and Lactation on the Pre- and Postnatal Development of the Mouse Immune System

Pauline L. Martin, Joel B. Cornacoff, George Treacy, +5

International Journal of Toxicology

ImmunologyGynecologyPathologyImmunologic MechanismImmune System +21