Optical Resolution of 2,2′,6,6′-Tetrafluorobiphenyl-3,3′-dicarboxylic Acid

Abstract

Abstract Optically active (−)- and (+)-2,2′,6,6′-tetrafluorobiphenyl-3,3′-dicarboxylic acids were obtained through brucine salts. The half-life times for racemization of their dimethyl esters were estimated at various temperatures and the activation energy was calculated to be 25.6 kcal/mol.