Concepedia

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

John R. James, Ronald D. Vale

Nature · 2012 · 339 citations · 27 references

DOI

Concepts

References

27

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

David L. Porter, Bruce L. Levine, Michael Kalos et al. · New England Journal of Medicine · 2011 · 3.5K citations · Full text

, , +17

Three-dimensional segregation of supramolecular activation clusters in T cells

Colin R. F. Monks, Benjamin A. Freiberg, Hannah Kupfer et al. · Nature · 1998 · 2.3K citations

, , +16

T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster

Rajat Varma, Gabriele Campi, Tadashi Yokosuka et al. · Immunity · 2006 · 878 citations · Full text

, , +16

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

Bryan Irving, Arthur Weiss · Cell · 1991 · 797 citations

, , +14

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76

Tadashi Yokosuka, Kumiko Sakata-Sogawa, Wakana Kobayashi et al. · Nature Immunology · 2005 · 694 citations

, , +14