Tadashi Yokosuka

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

Tadashi Yokosuka, Masako Takamatsu, Wakana Kobayashi-Imanishi et al. · The Journal of Experimental Medicine · 2012 · 1.1K citations · Full text

T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster

Rajat Varma, Gabriele Campi, Tadashi Yokosuka et al. · Immunity · 2006 · 864 citations · Full text

Signal Transduction, Tumor Microenvironment, Cell Interaction +8

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76

Tadashi Yokosuka, Kumiko Sakata-Sogawa, Wakana Kobayashi et al. · Nature Immunology · 2005 · 686 citations

T Cell Activation, Signal Transduction, T-regulatory Cell +6

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

Tadashi Yokosuka, Wakana Kobayashi, Kumiko Sakata-Sogawa et al. · Immunity · 2008 · 298 citations · Full text

Signal Transduction, Adaptive Immune System, Immunology +11

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

Masahiro Okada, Shunsuke Chikuma, Taisuke Kondo et al. · Cell Reports · 2017 · 230 citations · Full text

T-regulatory Cell, Immunology, Cell Death +17