Downregulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growth

Insulin signalling and the regulation of glucose and lipid metabolism

Alan R. Saltiel, C. Ronald Kahn · Nature · 2001 · 5.2K citations · Full text

Metabolic Syndrome, Insulin Signaling, Signal Transduction +13

Disruption of IRS-2 causes type 2 diabetes in mice

Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery et al. · Nature · 1998 · 1.8K citations

Metabolic Syndrome, Medicine, Diabetes +5

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

M.Dodson Michael, Rohit Kulkarni, Catherine Postic et al. · Molecular Cell · 2000 · 1.2K citations · Full text

Insulin Resistance, Metabolic Syndrome, Insulin Signaling +15

Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

Kohjiro Ueki, Tatsuya Kondo, C. Ronald Kahn · Molecular and Cellular Biology · 2004 · 673 citations · Full text

Immunology, Insulin Receptor, Insulin Signaling +20

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

Jane K. Howard, Belinda J. Cave, Laura Oksanen et al. · Nature Medicine · 2004 · 486 citations

Obesity, Metabolic Syndrome, Nutrition +12