Codon optimization and expression of irisin in Pichia pastoris GS115

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Pontus Boström, Jun Wu, Mark P. Jedrychowski et al. · Nature · 2012 · 4.7K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

Yuan Zhang, Rui Li, Yan Meng et al. · Diabetes · 2013 · 729 citations · Full text

Life Sciences, Biochemistry, Physiology +16

Humanization of Yeast to Produce Complex Terminally Sialylated Glycoproteins

Stephen R. Hamilton, Robert C. Davidson, Natarajan Sethuraman et al. · Science · 2006 · 501 citations

Life Sciences, Biochemistry, Biotechnology +17

Lower circulating irisin is associated with type 2 diabetes mellitus

Jianjun Liu, Melvin D.S. Wong, Wan Ching Toy et al. · Journal of Diabetes and its Complications · 2013 · 451 citations

Medicine, Endocrinology, Internal Medicine +4

Effects of obesity, diabetes and exercise on <i>Fndc5</i> gene expression and irisin release in human skeletal muscle and adipose tissue: <i>in vivo</i> and <i>in vitro</i> studies

Tímea Kurdiová, Miroslav Baláž, M Vician et al. · The Journal of Physiology · 2013 · 398 citations · Full text

Medicine, Endocrinology, Physiology +17