Pharmacogenetics of cyclophosphamide in patients with hematological malignancies

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

Thomas Lang, Kathrin Klein, Joachim E. Fischer et al. · Pharmacogenetics · 2001 · 569 citations

Medicine, Genetics, Molecular Genetics +17

Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

Partha Pratim Roy, L J Yu, Charles L. Crespi et al. · Drug Metabolism and Disposition · 1999 · 319 citations

Medicine, Biochemistry, Pharmacology +17

Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6

Julia Kirchheiner, Christian D. Klein, Ingolf Meineke et al. · Pharmacogenetics · 2003 · 250 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Dexamethasone Enhances Constitutive Androstane Receptor Expression in Human Hepatocytes: Consequences on Cytochrome P450 Gene Regulation

Jean‐Marc Pascussi, Sabine Gerbal‐Chaloin, Jean‐Michel Fabre et al. · Molecular Pharmacology · 2000 · 246 citations

Medicine, Molecular Biology, Pharmacology +17

Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation

H-J Xie, Ümit Yaşar, S Lundgren et al. · The Pharmacogenomics Journal · 2003 · 215 citations

Medicine, Pharmacokinetics, Pharmacology +12