Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Linda B. Moore, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2000 · 938 citations

Medicine, Pharmacology, Toxicology +17

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

Linda B. Moore, Derek J. Parks, Stacey A. Jones et al. · Journal of Biological Chemistry · 2000 · 810 citations · Full text

Medicine, Biochemistry, Pharmacology +17

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of<i>CYP3A4</i>by Rifampicin through a Distal Enhancer Module

Bryan Goodwin, Ecushla Hodgson, Christopher Liddle · Molecular Pharmacology · 1999 · 643 citations

Medicine, Molecular Biology, Pharmacology +17

The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism

Theresa H. Sullivan-Klose, Burhan I. Ghanayem, Douglas A. Bell et al. · Pharmacogenetics · 1996 · 587 citations

Medicine, Genetics, Pharmacology +17