Concepedia

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o

Gilbert Diaz, Katina Daniell, Sandra Leitza, Ruth L. Martin, Zhi Su, Jeff S. McDermott, Bryan F. Cox, Gary A. Gintant

Journal of Pharmacological and Toxicological Methods · 2004 · 118 citations · 51 references

DOI

Concepts

References

51

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

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HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte

William C. Claycomb, Nicholas A. Lanson, Beverly S. Stallworth et al. · Proceedings of the National Academy of Sciences · 1998 · 1.5K citations

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Properties of HERG Channels Stably Expressed in HEK 293 Cells Studied at Physiological Temperature

Zhengfeng Zhou, Qiuming Gong, Bin Ye et al. · Biophysical Journal · 1998 · 735 citations · Full text

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The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: Clinical and regulatory implications Report on a Policy Conference of the European Society of Cardiology

Wilhelm Haverkamp · Cardiovascular Research · 2000 · 485 citations · Full text

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