ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

Cherrie K. Donawho, Yan Luo, Yanping Luo, +34

Clinical Cancer Research

A-317491, a novel potent and selective non-nucleotide antagonist of P2X ₃ and P2X _2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

Michael F. Jarvis, Edward C. Burgard, Steve McGaraughty, +22

Proceedings of the National Academy of Sciences

The Utility of hERG and Repolarization Assays in Evaluating Delayed Cardiac Repolarization: Influence of Multi-Channel Block

Ruth L. Martin, Jeff S. McDermott, Heinz J. Salmen, +3

Journal of Cardiovascular Pharmacology

Cardiac MuscleHeart FailurePharmacotherapyBiomedical EngineeringExperimental Pharmacology +15

The Canine Purkinje Fiber: An In Vitro Model System for Acquired Long QT Syndrome and Drug-Induced Arrhythmogenesis

Gary A. Gintant, James T. Limberis, Jeff S. McDermott, +2

Journal of Cardiovascular Pharmacology

Cardiac MuscleHeart FailurePathologyPharmacotherapyVitro Model System +14

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o

Gilbert Diaz, Katina Daniell, Sandra Leitza, +5

Journal of Pharmacological and Toxicological Methods

Predictive Screening ToolMembrane PreparationsMedicinePhysiologyMechanism Of Action +6

Utility of hERG Assays as Surrogate Markers of Delayed Cardiac Repolarization and QT Safety

Gary A. Gintant, Zhi Su, Ruth L. Martin, +1

Toxicologic Pathology

Cardiac MuscleSurrogate MarkersPharmacotherapyCardiac RepolarizationHyperpolarization (Biology) +15

Direct evidence for the role of neuropeptide Y in sympathetic nerve stimulation-induced vasoconstriction

Song‐Ping Han, Chun-Lian Yang, Xiaoli Chen, +3

American Journal of Physiology-Heart and Circulatory Physiology

Vascular BedNeurophysiologyMedicineSympathetic Nervous SystemPhysiology +12

Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose Polymerase Inhibitor ABT-888 Requires a Conversion of Single-Stranded DNA Damages to Double-Stranded DNA Breaks

Xuesong Liu, Yan Shi, Ran Guan, +17

Molecular Cancer Research

Dna DamageApoptosisSingle-stranded Dna DamagesMolecular BiologyCell Death +17

Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O₂consumption in dogs

Patricia N. Banfor, Lee C. Preusser, Thomas Campbell, +5

American Journal of Physiology-Heart and Circulatory Physiology

Animal PhysiologyCardiac FunctionVeterinary PhysiologyMolecular PhysiologyMedicine +13

Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster

Andrew King, Jason A. Segreti, Kelly J. Larson, +6

Journal of Pharmacology and Experimental Therapeutics