Deacetylase Inhibitors Dissociate the Histone-Targeting ING2 Subunit from the Sin3 Complex

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

Chunaram Choudhary, Chanchal Kumar, Florian Gnad et al. · Science · 2009 · 4K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Michael S. Finnin, Jill R. Donigian, Alona Cohen et al. · Nature · 1999 · 1.7K citations

Life Sciences, Medicinal Chemistry, Molecular Biology +12

FDA Approval Summary: Vorinostat for Treatment of Advanced Primary Cutaneous T-Cell Lymphoma

Bhupinder Mann, John R. Johnson, Martin H. Cohen et al. · The Oncologist · 2007 · 1.4K citations · Full text

Medicine, Oncology, Pharmacotherapy +14

Histone deacetylase inhibitor selectively induces p21 ^WAF1 expression and gene-associated histone acetylation

Victoria M. Richon, Todd W. Sandhoff, Richard A. Rifkind et al. · Proceedings of the National Academy of Sciences · 2000 · 1.1K citations · Full text

Medicine, Molecular Biology, Oncology +16

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

Xiaobing Shi, Tao Hong, Kay L. Walter et al. · Nature · 2006 · 927 citations · Full text

Life Sciences, Genetics, Molecular Biology +11