Concepedia

Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRASG-quadruplexes

Alexandro Membrino, Manikandan Paramasivam, Susanna Cogoi, Jawad Alzeer, Nathan W. Luedtke, Luigi E. Xodo

Chemical Communications · 2009 · 75 citations · 26 references

DOI

Concepts

Abstract

Guanidino-modified phthalocyanines are evaluated in vitro (polymerase-stop assays and FRET) and in cultured cells as G4-DNA ligands and modulators of gene transcription.

References

26

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- <i>MYC</i> transcription

Adam Siddiqui-Jain, Cory L. Grand, David J. Bearss et al. · Proceedings of the National Academy of Sciences · 2002 · 2.2K citations

, , +17

G-quadruplexes in promoters throughout the human genome

J Huppert, Shankar Balasubramanian · Nucleic Acids Research · 2006 · 1.3K citations · Full text

, , +12

An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation

Sunita Kumari, Anthony Bugaut, J Huppert et al. · Nature Chemical Biology · 2007 · 822 citations · Full text

, , +14

G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription

Susanna Cogoi, Luigi E. Xodo · Nucleic Acids Research · 2006 · 746 citations · Full text

, , +14

G-quadruplex nucleic acids as therapeutic targets

Shankar Balasubramanian, Stephen Neidle · Current Opinion in Chemical Biology · 2009 · 581 citations · Full text

, , +13