Concepedia

Effects of combined valproic acid and the epidermal growth factor/vascular endothelial growth factor receptor tyrosine kinase inhibitor AEE788 on renal cell carcinoma cell lines <i>in vitro</i>

Eva Juengel, Johanna Engler, Ausra Mickuckyte, Jon Jones, Lukasz Hudak, Dietger Jonas, Roman A. Blaheta

British Journal of Urology · 2009 · 21 citations · 29 references

DOI

Abstract

Both AEE788 and VPA profoundly block the interaction of RCC cells with endothelium and extracellular matrix and reduce tumour growth in vitro. Therefore, this combined regimen warrants further preclinical and possible clinical study for treating advanced RCC.

References

29

Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma

Robert J. Motzer, Thomas E. Hutson, Piotr Tomczak et al. · New England Journal of Medicine · 2007 · 5.7K citations · Full text

FAK integrates growth-factor and integrin signals to promote cell migration

David J. Sieg, Christof R. Hauck, Duško Ilić et al. · Nature Cell Biology · 2000 · 1.2K citations · Full text

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Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells.

Christof R. Hauck, David J. Sieg, Datsun A. Hsia et al. · PubMed · 2001 · 250 citations

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Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells

Wei-Jiunn Lee, Wen-Kang Chen, Chau-Jong Wang et al. · Toxicology and Applied Pharmacology · 2007 · 177 citations

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Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment.

Changqing Yang, Michael Zeisberg, Julie C. Lively et al. · PubMed · 2003 · 130 citations

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