Concepedia

Valproic Acid

Valproic Acid is a pharmacological agent classified as an anticonvulsant and mood-stabilizing drug, distinguished by its mechanism of enhancing gamma-aminobutyric acid (GABA) activity and inhibiting voltage-gated sodium channels, primarily utilized in the management of seizure disorders, bipolar disorder, and, investigatively, agitation associated with delirium.

5K

Publications

235.5K

Citations

20.4K

Authors

3.9K

Institutions

Publications per year

2017–2026

986

Variants

Valproate

Parents

Publications

5K

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Martin Göttlicher · The EMBO Journal · 2001 · 1.9K citations · Full text

, , +10

Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen

Christopher J. Phiel, Fang Zhang, Eric Yi‐Hsiu Huang et al. · Journal of Biological Chemistry · 2001 · 1.7K citations · Full text

, , +17

Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism

Tomasz Schneider, Ryszard Przewłocki · Neuropsychopharmacology · 2004 · 959 citations

, , +17

Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells

Jenny Hsieh, Kinichi Nakashima, Tomoko Kuwabara et al. · Proceedings of the National Academy of Sciences · 2004 · 722 citations · Full text

, , +17

A Comparison of Valproate with Carbamazepine for the Treatment of Complex Partial Seizures and Secondarily Generalized Tonic–Clonic Seizures in Adults

Richard H. Mattson, Joyce A. Cramer, Joseph F. Collins · New England Journal of Medicine · 1992 · 690 citations · Full text

, , +14

1–5 of 5K

Authors

20.4K

  1. HN
    Heinz Nau

    Freie Universität Berlin, Germany

    71 publications · 4.4K citations

    36

    h-index

  2. EP
    Emilio Perucca

    University of Pavia, Italy

    35 publications · 1.9K citations

    27

    h-index

  3. MB
    Meir Bialer

    Hebrew University of Jerusalem, Israel

    54 publications · 2K citations

    27

    h-index

  4. WL
    Wolfgang Löscher

    University of Veterinary Medicine Hannover, Foundation, Germany

    31 publications · 1.8K citations

    26

    h-index

  5. HB
    Hasan B. Alam

    Massachusetts General Hospital, United States

    39 publications · 1.4K citations

    24

    h-index

1–5 of 20.4K

Institutions

3.9K

  1. National Institutes of Health

    Bethesda, United States

    46 h-index

    261 publications

    29.6K citations

  2. Freie Universität Berlin

    Berlin, Germany

    40 h-index

    137 publications

    9.9K citations

  3. University of Washington

    Seattle, United States

    37 h-index

    269 publications

    13.2K citations

  4. University of British Columbia

    Vancouver, Canada

    35 h-index

    219 publications

    11.9K citations

  5. Harvard University

    Cambridge, United States

    31 h-index

    136 publications

    8.1K citations

  6. Hebrew University of Jerusalem

    Jerusalem, Israel

    30 h-index

    195 publications

    7.2K citations

  7. University of Michigan

    Ann Arbor, United States

    28 h-index

    236 publications

    14.7K citations

  8. University College London

    London, United Kingdom

    28 h-index

    136 publications

    7.1K citations

1–8 of 3.9K

Venues

  1. Epilepsia

    195 publications · 10.3K citations

    61

    h-index

  2. Neurology

    118 publications · 10.8K citations

    59

    h-index

  3. PubMed

    Repository · 299 publications · 9.9K citations

    48

    h-index

  4. PLoS ONE

    72 publications · 3.4K citations

    36

    h-index

  5. Therapeutic Drug Monitoring

    111 publications · 3.7K citations

    36

    h-index

1–5