Concepedia

Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Diagnostics

Kristina Lagerstedt‐Robinson, Thalia D. Liu, Jana Vandrovcová, B. Halvarsson, Mark Clendenning, Thierry Frébourg, Nikolaos G. Papadopoulos, K. W. Kinzler, Bert Vogelstein, Païvi Peltomäki,

JNCI Journal of the National Cancer Institute · 2007 · 219 citations · 46 references

DOIFull text

Open access

Abstract

Our findings suggest that missense MMR gene mutations are common in HNPCC and that germline MMR mutations are also found in patients with MSI-negative tumors.

References

46

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.6K citations · Full text

, , +5

The American Journal of Human Genetics

J. S. · Population · 1950 · 5.1K citations

, , +7

Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability

Asad Umar, C. Richard Boland, Jonathan P. Terdiman et al. · JNCI Journal of the National Cancer Institute · 2004 · 3.2K citations · Full text

, , +14

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

Yurij Ionov, Miguel A. Peinado, Sergei Malkhosyan et al. · Nature · 1993 · 2.7K citations

, , +6

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC☆

Hans F. A. Vasen, Peter H. Watson, Jukka‐Pekka Mecklin et al. · Gastroenterology · 1999 · 2.5K citations

, , +13