Microsatellite Instability

Microsatellite Instability is a molecular genetic phenomenon characterized by the accumulation of errors in repetitive DNA sequences due to defective DNA mismatch repair mechanisms.

Publications

243.7K

Citations

16.6K

Authors

2.9K

Institutions

Publications per year

2017–2026

468

Variants

Msi

Parents

Cancer Genetics

Children

Clonal Evolution In Microsatellite Instable TumorsDna Replication Error RepairImmune Checkpoint ResponseImmunohistochemistry For Mismatch Repair ProteinsMicrosatellite Instability AssaysMicrosatellite Instability BiomarkersMicrosatellite Instability ClassificationMicrosatellite Instability GenotypingMicrosatellite Instability In Colorectal CancerMicrosatellite Instability In Endometrial Cancer

Publications

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

C. Richard Boland, Stephen N. Thibodeau, Stanley R. Hamilton et al. · PubMed · 1998 · 4.1K citations

Life Sciences, Genetics, Oncology +17

Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability

Asad Umar, C. Richard Boland, Jonathan P. Terdiman et al. · JNCI Journal of the National Cancer Institute · 2004 · 3.2K citations · Full text

Life Sciences, Genetics, Oncology +17

Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study

Aurélien Marabelle, Dung T. Le, Paolo A. Ascierto et al. · Journal of Clinical Oncology · 2019 · 3K citations · Full text

Life Sciences, Immunology, Oncology +17

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

Michael J. Overman, Ray McDermott, Joseph L. Leach et al. · The Lancet Oncology · 2017 · 2.8K citations · Full text

Medicine, Genetics, Oncology +14

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

Fredrick S. Leach, Nicholas C. Nicolaides, Nickolas Papadopoulos et al. · Cell · 1993 · 2.3K citations

Life Sciences, Genetics, Molecular Genetics +17

1–5 of 3K

Authors

16.6K

SN
Stephen N. Thibodeau
Mayo Clinic, United States
49 publications · 16.8K citations
39
h-index
JY
Joanne Young
QIMR Berghofer Medical Research Institute, Australia
36 publications · 7.2K citations
30
h-index
CR
C. Richard Boland
Baylor University Medical Center, United States
33 publications · 11.5K citations
29
h-index
MV
Magnus von Knebel Doeberitz
Heidelberg University, Germany
34 publications · 2.6K citations
28
h-index
MK
Matthias Kloor
Heidelberg University, Germany
31 publications · 2.1K citations
26
h-index

1–5 of 16.6K

Institutions

2.9K

1–8 of 2.9K

Venues

PubMed
Repository · 319 publications · 38.2K citations
104
h-index
International Journal of Cancer
129 publications · 7.4K citations
54
h-index
British Journal of Cancer
BJC · 71 publications · 4.8K citations
43
h-index
Journal of Clinical Oncology
60 publications · 15.8K citations
43
h-index
Clinical Cancer Research
51 publications · 5K citations
38
h-index

1–5