An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine

The Sensitivity of Single-Strand Conformation Polymorphism Analysis for the Detection of Single Base Substitutions

Val C. Sheffield, John S. Beck, Anne E. Kwitek et al. · Genomics · 1993 · 675 citations

Life Sciences, Genetics, Molecular Genetics +8

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

Ida Johansson, E Lundqvist, Leif Bertilsson et al. · Proceedings of the National Academy of Sciences · 1993 · 647 citations

Medicine, Genetics, Molecular Genetics +17

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

Markus H. Heim, Urs Meyer · The Lancet · 1990 · 451 citations

Life Sciences, Genetics, Molecular Genetics +7

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

Shioko Kimura, M Umeno, Radek C. Skoda et al. · PubMed · 1989 · 407 citations

Medicine, Genetics, Molecular Genetics +12

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

Masaaki Kagimoto, Markus H. Heim, Keiko Kagimoto et al. · Journal of Biological Chemistry · 1990 · 267 citations · Full text

Medicine, Genetics, Pharmacology +17