Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +16

SEROLOGICAL EVIDENCE OF AN ASSOCIATION OF A NOVEL CHLAMYDIA, TWAR, WITH CHRONIC CORONARY HEART DISEASE AND ACUTE MYOCARDIAL INFARCTION

Pekka Saikku, Kari Mattila, Markku S. Nieminen et al. · The Lancet · 1988 · 2K citations

Medicine, Cardiology, Microbiology +11

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Emily Pisha, Heebyung Chai, Ik‐Soo Lee et al. · Nature Medicine · 1995 · 886 citations

Life Sciences, Medicinal Chemistry, Pharmacology +14

Association of Chlamydia pneumoniae (Strain TWAR) Infection With Wheezing, Asthmatic Bronchitis, and Adult-Onset Asthma

David L. Hahn · JAMA · 1991 · 556 citations

Veterinary Medicine, Infectious Diseases, Internal Medicine +15