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Discovery of (R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist

Emmanuel Pinard, Alexander Alanine, Anne Bourson, Bernd Büttelmann, Ramanjit Gill, Marie‐Paule Heitz, Georg Jaeschke, Vincent Mutel, Gerhard Trube, R. Wyler

Bioorganic & Medicinal Chemistry Letters · 2001 · 18 citations · 18 references

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18

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

Hannah Monyer, Rolf Sprengel, Ralf Schoepfer et al. · Science · 1992 · 2.5K citations

, , +15

Molecular cloning and characterization of the rat NMDA receptor

Koki Moriyoshi, Masayuki Masu, Takahiro Ishii et al. · Nature · 1991 · 1.8K citations

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Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

Keith Williams · Molecular Pharmacology · 1993 · 853 citations

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Ro 25–6981, a Highly Potent and Selective Blocker of N-Methyl-d-aspartate Receptors Containing the NR2B Subunit. Characterization in Vitro

G. Fischer, Vincent Mutel, Gerhard Trube et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 484 citations

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Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn

S. Boyce, A. C. Wyatt, J.K. Webb et al. · Neuropharmacology · 1999 · 338 citations

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