Polymorphisms in Folate, Pyrimidine, and Purine Metabolism Are Associated with Efficacy and Toxicity of Methotrexate in Psoriasis

A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity

Ilan Weisberg, Pamela V. Tran, Benedicte Christensen et al. · Molecular Genetics and Metabolism · 1998 · 1.3K citations

Life Sciences, Genetics, Molecular Genetics +11

Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5'-terminal Regulatory Region of the Human Gene for Thymidylate Synthase.

Nobuyuki Horie, Hideo Aiba, Katsuhiko Oguro et al. · Cell Structure and Function · 1995 · 550 citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity.

Michael V Mandola, Jan Stoehlmacher, Susan Muller‐Weeks et al. · PubMed · 2003 · 363 citations

Life Sciences, Genetics, Molecular Biology +14

Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis

Thierry Dervieux, Daniel E. Furst, Diana Orentas Lein et al. · Arthritis & Rheumatism · 2004 · 334 citations

Life Sciences, Genetics, Pharmacology +17

A Polymorphism (80G->A) in the Reduced Folate Carrier Gene and Its Associations with Folate Status and Homocysteinemia

Abalo Chango, Nathalie Emery‐Fillon, G. Potier de Courcy et al. · Molecular Genetics and Metabolism · 2000 · 301 citations

Life Sciences, Genetics, Molecular Genetics +13