Proliferation-dependency of folylpolyglutamyl synthetase activity in maturating luminal epithelial cells of mouse small intestine

New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

Francis M. Sirotnak, Joseph I. DeGraw, D. M. Moccio et al. · Cancer Chemotherapy and Pharmacology · 1984 · 143 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Development of Target-Oriented Anticancer Drugs

Yung‐Chi Cheng, Barry Goz, Mimi Minkoff et al. · American Journal of Clinical Oncology · 1984 · 125 citations

Medicine, Medicinal Chemistry, Oncology +12

Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.

Lawrence L. Samuels, D. M. Moccio, Francis M. Sirotnak · PubMed · 1985 · 72 citations

Medicine, Oncology, Pharmacology +10

Role of folylpolyglutamate synthetase in the regulation of methotrexate polyglutamate formation in H35 hepatoma cells.

Thomas Johnson, Muraleedharan G. Nair, John Galivan · PubMed · 1988 · 28 citations

Life Sciences, Biochemistry, Cellular Biochemistry +7

Proposed mechanism of therapeutic selectivity for 9-beta-D-arabinofuranosyl-2-fluoroadenine against murine leukemia based upon lower capacities for transport and phosphorylation in proliferative intestinal epithelium compared to tumor cells.

José Barrueco, Ditte Jacobsen, Chao‐Sung Chang et al. · PubMed · 1987 · 27 citations

Medicine, Oncology, Pharmacology +11