Paraoxonase 1 (PON1) reduces macrophage inflammatory responses

PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

Mohamed Amine Bouhlel, Bruno Derudas, Elena Rigamonti et al. · Cell Metabolism · 2007 · 1.3K citations · Full text

Life Sciences, Cell Biology, Immunology +16

Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.

Mira Rosenblat, C L Bisgaier, Roger S. Newton et al. · Journal of Clinical Investigation · 1998 · 1.2K citations · Full text

Life Sciences, Biochemistry, Lipid Biochemistry +16

Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

A. D. Watson, J A Berliner, Susan Hama et al. · Journal of Clinical Investigation · 1995 · 1.2K citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Decreased Atherosclerotic Lesion Formation in Human Serum Paraoxonase Transgenic Mice

Aaron D. Tward, Yu-Rong Xia, Yi-Shou Shi et al. · Circulation · 2002 · 454 citations

Life Sciences, Biochemistry, Genetics +12

Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways

Giulia Chinetti, Morgane Baron, Mohamed Amine Bouhlel et al. · Circulation Research · 2011 · 373 citations · Full text

Life Sciences, Cardiology, Immunology +15