Receptor–Ligand Interactions Studied with Homogeneous Fluorescence-Based Assays Suitable for Miniaturized Screening

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Pharmacy, Medicinal Chemistry, Drug Design +16

The Photon Counting Histogram in Fluorescence Fluctuation Spectroscopy

Yan Chen, Joachim D. Müller, Peter T. C. So et al. · Biophysical Journal · 1999 · 677 citations · Full text

Natural Sciences, Biophysics, Physics +13

Fluorescence-intensity distribution analysis and its application in biomolecular detection technology

Peet Kask, Kaupo Palo, Dirk Ullmann et al. · Proceedings of the National Academy of Sciences · 1999 · 455 citations

Natural Sciences, Biophysics, Molecular Biology +17

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

Shigeki Higashiyama, Kwai Man Lau, Gail E. Besner et al. · Journal of Biological Chemistry · 1992 · 349 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13