Concepedia

GilR, an Unusual Lactone‐Forming Enzyme Involved in Gilvocarcin Biosynthesis

Madan K. Kharel, Pallab Pahari, Hui Lian, Jürgen Rohr

ChemBioChem · 2009 · 30 citations · 22 references

DOIFull text

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Concepts

Abstract

Last at last: The terminal step of the gilvocarcin V (GV) biosynthetic pathway is an unusual lactone formation. Here we show that the enzyme, GilR, dehydrogenates the hemiacetal moiety of pregilvocarcin V to the lactone found in GV by using covalently bound FAD.

References

22

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

Robert Hertzberg, Mary Jo Caranfa, Sidney M. Hecht · Biochemistry · 1989 · 552 citations

, , +10

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

Christine Jaxel, Kurt W. Kohn, Mansukh C. Wani et al. · PubMed · 1989 · 450 citations

, , +14

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

Shiou‐Chuan Tsai, Larry J. W. Miercke, J. Krucinski et al. · Proceedings of the National Academy of Sciences · 2001 · 214 citations · Full text

, , +17

The Interconversion Kinetics, Equilibrium, and Solubilities of the Lactone and Hydroxyacid Forms of the HMG-CoA Reductase Inhibitor, CI-981

Albert S. Kearney, Lee F. Crawford, Surendra C. Mehta et al. · Pharmaceutical Research · 1993 · 128 citations

, , +6

Characterization of Kinetics and Products of the Baeyer−Villiger Oxygenase MtmOIV, The Key Enzyme of the Biosynthetic Pathway toward the Natural Product Anticancer Drug Mithramycin from <i>Streptomyces </i><i>a</i><i>rgillaceus</i>

Miranda Gibson, Mohammad Nur‐e‐Alam, Fredilyn Lipata et al. · Journal of the American Chemical Society · 2005 · 121 citations

, , +17