Impact of hepatitis B virus basic core promoter mutations on T cell response to an immunodominant HBx‐derived epitope†

Abstract

Wild-type and variant peptides may represent potential tools for monitoring the HBV-specific T cell responses involved in sequence evolution during disease progression. Finally, the degenerate HLA-DR binding of this promiscuous, immunodominant peptide would make it a valuable component of vaccines for protecting large and ethnically diverse patient populations.