Aging-related Correlation of Insulin-degrading Enzyme with γ-Secretase-generated Products Involving Insulin and Glucose Levels in Transgenic Mice

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain <i>in vivo</i>

Wesley Farris, Stefan Mansourian, Yang Chang et al. · Proceedings of the National Academy of Sciences · 2003 · 1.5K citations · Full text

Life Sciences, Genetics, Neuroscience +15

Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

Konstantinos Vekrellis, Zhen Ye, Wei Qiao Qiu et al. · Journal of Neuroscience · 2000 · 484 citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Analysis of Heterogeneous βA4 Peptides in Human Cerebrospinal Fluid and Blood by a Newly Developed Sensitive Western Blot Assay

Nobuo Ida, Tobias Hartmann, Johannes Pantel et al. · Journal of Biological Chemistry · 1996 · 479 citations · Full text

Medicine, Neurology, Neuroscience +17

Insulin and Cognitive Function in an Elderly Population: The Rotterdam Study

Ronald P. Stolk, Monique M.B. Breteler, Alewijn Ott et al. · Diabetes Care · 1997 · 212 citations

Medicine, Endocrinology, Geriatric Medicine +17