Proceedings of the National Academy of Sciences · 1990 · 96 citations · 23 references
Life SciencesImmunologyMolecular BiologyCellular ImmunologyMolecular ImmunologyVaccine ImmunologyAntigen PresentationAntigen ProcessingAntigen RecognitionHistocompatibility AntigensHuman Leukocyte Antigen SystemMajor Histocompatibility ComplexMajor Histocompatibility Complex (Mhc) PresentationMhc Binding AntigensMhc Class Ii MoleculesMhc-peptide Binding SpecificityMhc-peptide RecognitionPeptide-major Histocompatibility Complex Recognition
T lymphocytes recognize endogenously produced antigenic peptides in association with major histocompatibility complex (MHC)-encoded molecules. Peptides from the extracellular fluid can be displayed in association with class I and class II MHC molecules. Here we report that mature Kb class I MHC molecules bind peptides upon dissociation and reassociation of their light chain. Intact Kb heterodimers, unlike class II MHC molecules, are relatively unreceptive to binding peptides. This property may maintain segregation of class I and class II MHC-restricted peptides and has implications for the use of peptides as vaccines.
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Structure of the human class I histocompatibility antigen, HLA-A2
Pamela J. Björkman, Mark A. Saper, Boudjéma Samraoui et al. · Nature · 1987 · 3.5K citations
Binding of immunogenic peptides to Ia histocompatibility molecules
Bruce Babbitt, Paul M. Allen, Gary R. Matsueda et al. · Nature · 1985 · 1.2K citations