Impact of the Superoxide Dismutase 2 Val16Ala Polymorphism on the Relationship between Valproic Acid Exposure and Elevation of γ-Glutamyltransferase in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis - Concepedia

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Impact of the Superoxide Dismutase 2 Val16Ala Polymorphism on the Relationship between Valproic Acid Exposure and Elevation of γ-Glutamyltransferase in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

DOI Full Paper Access

37

Citations

28

References

2014

Year

Naoki Ogusu, Junji Saruwatari, Hiroo Nakashima, Madoka Noai, Miki Nishimura, Mariko Deguchi, Kentaro Oniki, Norio Yasui‐Furukori, Sunao Kaneko, Takateru Ishitsu,

Abstract

Our results showed that the SOD2 Val16Ala polymorphism has an impact on the relationship between VPA exposure and γ-GT elevation in patients with epilepsy. These results suggest that determining the SOD2 genotype could be helpful for preventing the VPA-induced γ-GT elevation.

References

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