Advances in Hematology · 2012 · 61 citations · 37 references
MedicineCancer BiologyOncologyCell SignalingMolecular OncologySignal TransductionAngiogenesisAngiogenesis In CancerCancer Cell SignalingCancer ProgressionOncogenic Signaling PathwaysSignal Transduction In CancerPhosphatidylinositol 3-Kinase-akt PathwayPhosphatidylinositol 3-Kinase-akt SignalingPi3 Kinase-akt SignalingPi3k SignalingPi3k-akt Signaling PathwayPten InactivationPten SignalingVascular Endothelial Growth Factor
PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The mechanism by which the signaling pathway regulates angiogenesis remains to be further elucidated. However, it has become an attractive target for drug therapy against leukemia, because angiogenesis is a key process in malignant cell growth. In this paper, we will focus on the roles and mechanisms of PI3K/AKT/PTEN pathway in regulating angiogenesis.
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Andrew R. Tee, Brendan D. Manning, Philippe P. Roux et al. · Current Biology · 2003 · 1.2K citations · Full text
Bing‐Hua Jiang, Jenny Z. Zheng, Masahiro Aoki et al. · Proceedings of the National Academy of Sciences · 2000 · 527 citations