Putting nature back into drug discovery

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Is There a Difference between Leads and Drugs? A Historical Perspective

Tudor I. Oprea, A. M. Davis, Simon J. Teague et al. · Journal of Chemical Information and Computer Sciences · 2001 · 775 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds

Thomas Henkel, Roger M. Brunne, Hartwig Müller et al. · Angewandte Chemie International Edition · 1999 · 618 citations

Pharmacy, Chemistry, Medicinal Chemistry +15

Strategies for discovering drugs from previously unexplored natural products

Alan R. Harvey · Drug Discovery Today · 2000 · 542 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Synthesis of epothilones A and B in solid and solution phase

K. C. Nicolaou, Nicolas Winssinger, Joaquı́n Pastor et al. · Nature · 1997 · 399 citations

Natural Sciences, Chemistry, Crystal Structure +6