Concepedia

Influence of Uridine Diphosphate‐Glucuronyltransferase 2<scp>B</scp>7 (<i><scp>UGT</scp>2B7</i>) Variants on Postoperative Buprenorphine Analgesia

José A. Sastre, Gonzálo Varela, Mónica López, Clemente Muriel, Rogelio González‐Sarmiento

Pain Practice · 2013 · 31 citations · 14 references

DOI

Abstract

The presence of the SNP 802C>T UGT2B7 (UGT2B7*2/*2) is associated with a worse analgesic response to transdermal buprenorphine in the postoperative period of thoracic surgery.

References

14

Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction

Cherie E. Bond, K. Steven LaForge, Mingting Tian et al. · Proceedings of the National Academy of Sciences · 1998 · 1.1K citations · Full text

Human UGT2B7 catalyzes morphine glucuronidation.

Birgit L. Coffman, Gladys R. Rios, Christopher D. King et al. · PubMed · 1997 · 426 citations

, , +13

The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).

Birgit L. Coffman, Christopher D. King, Gladys R. Rios et al. · PubMed · 1998 · 326 citations

, , +17

Human Opioid Receptor A118G Polymorphism Affects Intravenous Patient-controlled Analgesia Morphine Consumption after Total Abdominal Hysterectomy

Wen‐Ying Sylvia Chou, Cheng-Haung Wang, Ping-Hsin Liu et al. · Anesthesiology · 2006 · 307 citations

Pharmacogenetics of Neonatal Opioid Toxicity Following Maternal Use of Codeine During Breastfeeding: A Case–Control Study

P Madadi, Andrea Gaedigk, JS Leeder et al. · Clinical Pharmacology & Therapeutics · 2008 · 303 citations