Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: From in vitro to in vivo

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

R. Clark Billinghurst, Leif Dahlberg, Mirela Ionescu et al. · Journal of Clinical Investigation · 1997 · 975 citations · Full text

Medicine, Orthopaedic Surgery, Pathology +14

Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage

Patrick Garnero · Annals of the Rheumatic Diseases · 2001 · 480 citations · Full text

Medicine, Orthopaedic Surgery, Orthopedic Surgery +16

Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis

Patrick Garnero, X Ayral, Jean‐Charles Rousseau et al. · Arthritis & Rheumatism · 2002 · 398 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17

Collagen type II C-telopeptide fragments as an index of cartilage degradation

Stephan Christgau, Patrick Garnero, Christian Fledelius et al. · Bone · 2001 · 287 citations

Medicine, Orthopedic Surgery, Cartilage Repair +11

Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13

William Ka Kei Wu, R. Clark Billinghurst, Isabelle Pidoux et al. · Arthritis & Rheumatism · 2002 · 249 citations

Medicine, Orthopaedic Surgery, Pathology +17