Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics

Rand Jenkins, Jeffrey X. Duggan, Anne‐Françoise Aubry, +12

The AAPS Journal

EngineeringBiochemistryMedicineBioanalysisMass Spectrometry +8

Mass spectrometry compatibility of two-dimensional gel protein stains

Wendy M. Lauber, James A. Carroll, Dawn Dufield, +3

Electrophoresis

Proteomic TechnologyBiochemistryMedicineNatural SciencesBioanalysis +13

Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: From in vitro to in vivo

Olga V. Nemirovskiy, Dawn Dufield, T. Sunyer, +3

Analytical Biochemistry

Biomarker (Medicine)FibrosisSclerodermaMatrix Metalloproteinase ActivityMedicine +12

Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor

Priya Chockalingam, Wei Sun, M.A. Rivera-Bermudez, +8

Osteoarthritis and Cartilage

InflammationAggrecanase Specific InhibitorRheumatoid DisorderMusculoskeletal ResearchAnti-inflammatory +10

2013 White Paper on Recent Issues in Bioanalysis: ‘ <i>Hybrid</i> ’ – The Best of LBA and LCMS

Lauren Stevenson, Fabio Garofolo, Binodh DeSilva, +57

Bioanalysis

White PaperChemical BiologyBioanalysisAnalytical ChemistryClinical Chemistry +17

2014 White Paper on Recent Issues in Bioanalysis: A Full Immersion in Bioanalysis (Part 2 – Hybrid LBA/LCMS, ELN &amp; Regulatory Agencies’ Input)

Dawn Dufield, Hendrik Neubert, Fabio Garofolo, +48

Bioanalysis

EngineeringWhite PaperInvolved LcmsFull ImmersionBioanalysis +23

Pharmacology of PF-4191834, a Novel, Selective Non-Redox 5-Lipoxygenase Inhibitor Effective in Inflammation and Pain

Jaime L. Masferrer, Ben S. Zweifel, Medora M. Hardy, +5

Journal of Pharmacology and Experimental Therapeutics

An immunoaffinity liquid chromatography–tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation

Dawn Dufield, Olga V. Nemirovskiy, Michael G. Jennings, +3

Analytical Biochemistry

Endogenous Aggrecan FragmentsEngineeringMedicineBioanalysisImmunology +11

Online immunoaffinity LC/MS/MS. A general method to increase sensitivity and specificity: How do you do it and what do you need?

Dawn Dufield, Melissa R. Radabaugh

Methods

AllergyImmunoengineeringImmunologyImmunophenotypingAutoimmunity +8

Host limits to accurate human growth hormone production in multiple plant systems

Douglas A. Russell, Lori A. Spatola, Titik Dian, +4

Biotechnology and Bioengineering

EngineeringBotanyGeneticsAgricultural EconomicsEscherichia Coli +19