Dose-Finding and Pharmacokinetic Study to Optimize the Dosing of Irinotecan According to the <i>UGT1A1</i> Genotype of Patients With Cancer - Concepedia

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Dose-Finding and Pharmacokinetic Study to Optimize the Dosing of Irinotecan According to the <i>UGT1A1</i> Genotype of Patients With Cancer

DOI Full Paper Access

137

Citations

22

References

2014

Year

Federico Innocenti, Richard L. Schilsky, Jacqueline Ramı́rez, Linda Janisch, Samir D. Undevia, Larry House, Soma Das, Kehua Wu, Michelle Turcich, Robert Marsh,

Journal of Clinical Oncology

Abstract

The UGT1A1*28 genotype can be used to individualize dosing of irinotecan. Additional studies should evaluate the effect of genotype-guided dosing on efficacy in patients receiving irinotecan.

References

	Year	Citations

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