Concepedia

A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes

Siddhartha Bhoopathy, Baomin Xin, S E Unger, H. Thomas Karnes

Journal of Pharmaceutical and Biomedical Analysis · 2004 · 16 citations · 16 references

Concepts

MedicinePharmacokineticsPharmacologyDrug MetabolismMetabolomicsPharmacogeneticsBioanalytical Method ValidationCytochrome P450 EnzymesCytochrome P450-mediated MetabolismIn Vitro Metabolic AssaysMetabolite ExtractionCyp2d6 Drug MetabolismCytochrome P450 2D6Cytochrome P450 Drug MetabolismCytochrome P450 Metabolism AssaysMicrosomal Drug MetabolismMicrosomal Incubation AssaysPharmacokinetic Screening

References

16

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

Thomas Kronbach, Daniel Mathys, Makoto Umeno et al. · Molecular Pharmacology · 1989 · 535 citations

Medicine, Pharmacology, Biochemical Pharmacology +15

Microtiter Plate Assays for Inhibition of Human, Drug-Metabolizing Cytochromes P450

Charles L. Crespi, Vaughn P. Miller, Bruce W. Penman · Analytical Biochemistry · 1997 · 408 citations

Medicine, Biochemistry, Pharmacology +12

Pharmacogenetics of drug metabolism

W. Kalow · Trends in Pharmacological Sciences · 1980 · 289 citations

Medicine, Pharmacokinetics, Pharmacology +12

Measurement of Michaelis Constants for Cytochrome P450-Mediated Biotransformation Reactions Using a Substrate Depletion Approach

R. Scott Obach, Anne E. Reed‐Hagen · Drug Metabolism and Disposition · 2002 · 187 citations

Medicine, Pharmacokinetics, Pharmacology +17

Use of in vitro human metabolism studies in drug development

A. David Rodrigues · Biochemical Pharmacology · 1994 · 143 citations

Pharmacy, Pharmacokinetics, Pharmacology +12