Use of in vitro human metabolism studies in drug development

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

F. Peter Guengerich, Dong‐Hyun Kim, M. Iwasaki · Chemical Research in Toxicology · 1991 · 1.2K citations

Medicine, Oncology, Toxicology +8

Terfenadine-Ketoconazole Interaction

Peter K. Honig · JAMA · 1993 · 658 citations

Medicine, Pharmacokinetics, Pharmacology +15

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Marguerite A. Butler, M. Iwasaki, F. Peter Guengerich et al. · Proceedings of the National Academy of Sciences · 1989 · 638 citations · Full text

Medicine, Pharmacology, Toxicology +17

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

Allan E. Rettie, Kenneth R. Korzekwa, Kent L. Kunze et al. · Chemical Research in Toxicology · 1992 · 602 citations

Medicine, Pharmacology, Toxicology +17

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

Raimund M. Peter, Ronald Boecker, Philippe Beaune et al. · Chemical Research in Toxicology · 1990 · 535 citations

Medicine, Pharmacology, Toxicology +11