In Vivo Functioning and Transplantable Mature Pancreatic Islet-Like Cell Clusters Differentiated from Embryonic Stem Cell

Abstract

Our results provide evidence that ES cells could differentiate to functioning and transplantable mature pancreatic islet-like cell clusters using our newly developed differentiation method without employing gene transfer technique. This study may lead to a basis for production of indefinite sources of islets that could be applicable for future clinical trial.