Concepedia

Islet Cell Differentiation

Islet Cell Differentiation is a developmental biological process in which pancreatic progenitor cells undergo specialized cell fate commitment to form functionally distinct endocrine cell types within the pancreatic islets, such as alpha, beta, delta, gamma, and epsilon cells, through tightly regulated transcriptional and signaling mechanisms.

1.1K

Publications

94.2K

Citations

4.9K

Authors

1.1K

Institutions

Publications per year

2017–2026

169

Parents

Publications

1.1K

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Yuval Dor, Juliana Brown, Olga I. Martinez et al. · Nature · 2004 · 2.2K citations

, , +14

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

Guoqiang Gu, Jolanta Dubauskaite, Douglas A. Melton · Development · 2002 · 1.5K citations

, , +16

<i>neurogenin3</i> is required for the development of the four endocrine cell lineages of the pancreas

Gérard Gradwohl, Andrée Dierich, Marianne LeMeur et al. · Proceedings of the National Academy of Sciences · 2000 · 1.5K citations

, , +17

Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development

Angela J. Churchill, Giselle Domínguez Gutiérrez, Ruth A. Singer et al. · eLife · 2017 · 1.3K citations · Full text

, , +15

Induction of Pancreatic Differentiation by Signals from Blood Vessels

Eckhard Lammert, Ondine Cleaver, Douglas A. Melton · Science · 2001 · 1.1K citations

, , +17

1–5 of 1.1K

Authors

4.9K

  1. SB
    Susan Bonner‐Weir

    Joslin Diabetes Center, United States

    27 publications · 4.7K citations

    21

    h-index

  2. TO
    Timo Otonkoski

    University of Helsinki, Finland

    20 publications · 1.8K citations

    18

    h-index

  3. MS
    Michael S. German

    University of California, San Francisco, United States

    19 publications · 3.7K citations

    17

    h-index

  4. LS
    Lori Sussel

    Columbia University, United States

    17 publications · 3.4K citations

    16

    h-index

  5. AS
    Arun Sharma

    Joslin Diabetes Center, United States

    16 publications · 3.2K citations

    16

    h-index

1–5 of 4.9K

Institutions

1.1K

  1. Harvard University

    Cambridge, United States

    38 h-index

    261 publications

    52.3K citations

  2. Vanderbilt University Medical Center

    Nashville, United States

    30 h-index

    119 publications

    11.5K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    30 h-index

    89 publications

    34K citations

  4. University of California, San Francisco

    San Francisco, United States

    28 h-index

    164 publications

    32.6K citations

  5. Inserm

    Paris, France

    25 h-index

    114 publications

    16.3K citations

  6. University of Pennsylvania

    Philadelphia, United States

    23 h-index

    76 publications

    11.3K citations

  7. Joslin Diabetes Center

    Boston, United States

    23 h-index

    156 publications

    28.8K citations

  8. Vanderbilt University

    Nashville, United States

    22 h-index

    61 publications

    8K citations

1–8 of 1.1K

Venues

  1. Diabetes

    93 publications · 11.2K citations

    55

    h-index

  2. Diabetologia

    42 publications · 2.9K citations

    29

    h-index

  3. Development

    29 publications · 7.5K citations

    27

    h-index

  4. PLoS ONE

    41 publications · 2K citations

    27

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 28 publications · 7.2K citations

    26

    h-index

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