TLR-Independent and P2X7-Dependent Signaling Mediate<i>Alu</i>RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy

Abstract

NF-κB and P2X7 are critical signaling intermediates in Alu RNA-induced inflammasome priming and RPE degeneration. These molecules are novel targets for rational drug development for geographic atrophy.