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Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity

Fulvio Chiacchiera, Alessandra Rossi, Sriganesh Jammula, Andrea Piunti, Andrea Scelfo, Paloma Ordóñez‐Morán, Joerg Huelsken, Haruhiko Koseki, Diego Pasini

Cell stem cell · 2015 · 130 citations · 30 references

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30

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature · 2009 · 7.2K citations

, , +14

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature · 2007 · 5.7K citations

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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

Patrice J. Morin, Andrew B. Sparks, Vladimír Kořínek et al. · Science · 1997 · 3.9K citations

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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC <sup>−/−</sup> Colon Carcinoma

Vladimír Kořínek, Nick Barker, Patrice J. Morin et al. · Science · 1997 · 3.3K citations

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Toshiro Sato, Johan H. van Es, Hugo J.G. Snippert et al. · Nature · 2010 · 2.5K citations

, , +15