Concepedia

IN VITRO AND IN VIVO EVALUATION OF THE METABOLISM AND BIOAVAILABILITY OF ESTER PRODRUGS OF MGS0039 (3-(3,4-DICHLOROBENZYLOXY)-2-AMINO-6-FLUOROBICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID), A POTENT METABOTROPIC GLUTAMATE RECEPTOR ANTAGONIST

Masato Nakamura, Yasunori Kawakita, Akito Yasuhara, Yoshiki Fukasawa, Kōji Yoshida, Kazunari Sakagami, Atsuro Nakazato

Drug Metabolism and Disposition · 2005 · 14 citations · 25 references

DOI

Concepts

References

25

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

Bita Moghaddam, Barbara W. Adams · Science · 1998 · 1K citations

, , +17

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

Kazumitsu Ueda, Noboru Okamura, Midori Hirai et al. · Journal of Biological Chemistry · 1992 · 676 citations · Full text

, , +15

Glutamate in CNS disorders as a target for drug development: an update

Chris G. Parsons, Wojciech Danysz, G. Quack · Drug News & Perspectives · 1998 · 447 citations

, , +17

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

James A. Monn, Matthew J. Valli, Steven M. Massey et al. · Journal of Medicinal Chemistry · 1997 · 393 citations

, , +17

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

Yusuke Tanigawara, Noboru Okamura, Midori Hirai et al. · Journal of Pharmacology and Experimental Therapeutics · 1992 · 336 citations

, , +17