Kazunari Sakagami

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

Shigeyuki Chaki, Ryoko Yoshikawa, Shiho Hirota et al. · Neuropharmacology · 2003 · 250 citations

Antidepressant-like Activity, Psychoactive Drug, Psychiatry +11

Synthesis, SARs, and Pharmacological Characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent, Selective, and Orally Active Group II Metabotropic Glutamate Receptor Agonists

Atsuro Nakazato, Toshihito Kumagai, Kazunari Sakagami et al. · Journal of Medicinal Chemistry · 2000 · 114 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Pharmacological Characterization +15

Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists

Atsuro Nakazato, Kazunari Sakagami, Akito Yasuhara et al. · Journal of Medicinal Chemistry · 2004 · 59 citations · Full text

Combinatorial Chemistry, Pharmaceutical Science, Pharmacotherapy +18

Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential

Akito Yasuhara, Masato Nakamura, Kazunari Sakagami et al. · Bioorganic & Medicinal Chemistry · 2006 · 43 citations

Medicinal Chemistry, Biochemistry, Medicine +10

Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist

Kazunari Sakagami, Akito Yasuhara, Shigeyuki Chaki et al. · Bioorganic & Medicinal Chemistry · 2008 · 19 citations · Full text

Pharmacological Study, Biochemistry, Medicine +6