MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

Shigeyuki Chaki, Ryoko Yoshikawa, Shiho Hirota, +9

Neuropharmacology

Antidepressant-like ActivityPsychoactive DrugPsychiatryFunctional SelectivityMedicine +9

Design, synthesis and structure–affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands

Taketoshi Okubo, Ryoko Yoshikawa, Shigeyuki Chaki, +2

Bioorganic & Medicinal Chemistry

Molecular PharmacologyPharmaceutical ChemistryDerivativesMedicineAryloxyanilide Derivatives +6

Synthesis, SARs, and Pharmacological Characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent, Selective, and Orally Active Group II Metabotropic Glutamate Receptor Agonists

Atsuro Nakazato, Toshihito Kumagai, Kazunari Sakagami, +7

Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryPharmacological CharacterizationBiochemistryCompound 4 +13

Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression

Tetsuo Hirano, Ryoko Yoshikawa, Hironori Harada, +3

Molecular Cancer

Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106

Shigeru Okuyama, Shigeyuki Chaki, Ryoko Yoshikawa, +6

Life Sciences

Molecular PharmacologyNeuropharmacological ProfileNeurophysiologyMedicinePsychotropic Medication +8

Binding characteristics of DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors

Shigeyuki Chaki, Takeo Funakoshi, Ryoko Yoshikawa, +5

European Journal of Pharmacology

Drug TargetBiochemistryFunctional SelectivityPeripheral Benzodiazepine ReceptorsMedicine +8

Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists

Atsuro Nakazato, Kazunari Sakagami, Akito Yasuhara, +5

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmaceutical SciencePharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +16

Design, synthesis, and structure–activity relationships of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands

Taketoshi Okubo, Ryoko Yoshikawa, Shigeyuki Chaki, +2

Bioorganic & Medicinal Chemistry

Molecular PharmacologyHeterocyclicMedicineNovel Tetracyclic CompoundsChemistry +4

Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential

Akito Yasuhara, Masato Nakamura, Kazunari Sakagami, +5

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesPsychotropic Medication +8

A selective dopamine D4 receptor antagonist, NRA0160: A preclinical neuropharmacological profile

Shigeru Okuyama, Naoya Kawashima, Shigeyuki Chaki, +9

Life Sciences

Preclinical Neuropharmacological ProfileMedicineFunctional SelectivityPsychopharmacologyNeuropharmacology +4