Taketoshi Okubo

Design, synthesis and structure–affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands

Taketoshi Okubo, Ryoko Yoshikawa, Shigeyuki Chaki et al. · Bioorganic & Medicinal Chemistry · 2003 · 157 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Receptor Binding, Behavioral, and Electrophysiological Profiles of Nonpeptide Corticotropin-Releasing Factor Subtype 1 Receptor Antagonists CRA1000 and CRA1001

Shigeru Okuyama, Shigeyuki Chaki, Naoya Kawashima et al. · Journal of Pharmacology and Experimental Therapeutics · 1999 · 153 citations · Full text

Medicine, Neuroscience, Pharmacology +15

Anxiolytic-Like and Antidepressant-Like Activities of MCL0129 (1-[(S)-2-(4-Fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a Novel and Potent Nonpeptide Antagonist of the Melanocortin-4 Receptor

Shigeyuki Chaki, Shiho Hirota, Takeo Funakoshi et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 118 citations · Full text

Medicine, Neuroscience, Pharmacology +14

Development of a Method for Evaluating Drug-Likeness and Ease of Synthesis Using a Data Set in Which Compounds Are Assigned Scores Based on Chemists' Intuition

Yuji Takaoka, Yutaka Endo, Susumu Yamanobe et al. · Journal of Chemical Information and Computer Sciences · 2003 · 96 citations

Pharmacy, Chemistry, Medicinal Chemistry +17

Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106

Shigeru Okuyama, Shigeyuki Chaki, Ryoko Yoshikawa et al. · Life Sciences · 1999 · 90 citations

Medicine, Neuroscience, Pharmacology +8