Concepedia

Regulation of 26S Proteasome Activity in Pulmonary Fibrosis

Nora Semren, Vanessa Welk, Martina Korfei, Ilona E. Keller, Isis E. Fernandez, Heiko Adler, Andreas Günther, Oliver Eickelberg, Silke Meiners

American Journal of Respiratory and Critical Care Medicine · 2015 · 46 citations · 26 references

DOI

Abstract

We identified Rpn6-dependent 26S proteasome activation as an essential feature of myofibroblast differentiation in vitro and in vivo, and our results suggest it has an important role in IPF pathogenesis.

References

26

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

Ganesh Raghu, Harold R. Collard, Jim Egan et al. · American Journal of Respiratory and Critical Care Medicine · 2011 · 7.1K citations · Full text

A gated channel into the proteasome core particle.

M. Groll, Michael H. Glickman, Daniel Finley et al. · Nature Structural Biology · 2000 · 800 citations

, , +7

Complete subunit architecture of the proteasome regulatory particle

Gabriel C. Lander, Eric Estrin, Mary E. Matyskiela et al. · Nature · 2012 · 615 citations

, , +6

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

Pádraig D’Arcy, Slavica Brnjic, Maria Hägg Olofsson et al. · Nature Medicine · 2011 · 493 citations

, , +10

New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis

Isis E. Fernandez, Oliver Eickelberg · The Lancet · 2012 · 429 citations

, , +11