Concepedia

<i>In vivo</i> demonstration of an active tumor pretargeting approach with peptide nucleic acid bioconjugates as complementary system

Anna Leonidova, Christian Foerster, Kristof Zarschler, M. Schubert, Hans‐Jürgen Pietzsch, Jörg Steinbach, Ralf Bergmann, Nils Metzler‐Nolte, Holger Stephan, Gilles Gasser

Chemical Science · 2015 · 42 citations · 60 references

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Concepts

Abstract

hybridization of the radiolabeled PNA with the antibody-PNA conjugate. Decisively, a high specific tumor accumulation was observed with a tumor-to-muscle ratio of >8, resulting in a clear visualization of the tumor by single photon emission computed tomography (SPECT).

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